HRT for climacteric syndrome. Prophylax-is of osteoporosis
History of, or predisposition to, thrombophlebitis, thromboembolic disorders, cere-brovascular disease. History of pruritus, during pregnancy deteriorating ,otosclerosis, idiopathic jaundice or pemphigus gestations (herpes gestations). Impaired hepatic excretory function such as Dubin-Johnson & Rotor syndromes. Sickle cell anaemia. Acute or chronic liver disease, jaundice, porphyria, disorders of lipid metabolism. Oestrogen dependent carcinomas, endometriosis, undiagnosed genital bleeding. Pregnancy. Lactation.
Hypertension, myocardial or renal dis-ease, asthma, varicose veins, epilepsy, chloasma, uterine fibromyomata. Examine BP, pelvic organs & breasts before & regularly during treatment. Adverse effects: Nausea, vomiting, weight gain, breast tenderness & enlargement, withdrawal bleeding, so-dium retention with oedema, liver function disorders, jaundice, rashes, chloasma, headache. Endometrial carcinoma in post-menopausal women.